Sensory Dysfunction Assessment in Carpal Tunnel Syndrome

Type of project: Translational, Nutraceutical and Personalized Medicine

Principal Investigator: Dr. K Ming Chan

Institutions Affiliated: Grant MacEwan University

Student: Christopher Clarke (UGRAD)

Awards funded to project:1

Background: Acetyl-L-Carnitine is a dietary supplement that aids in many metabolic processes, and has recently been considered as a treatment option for neuropathic pain. Carpal Tunnel Syndrome is a disorder characterized by such neuropathic pain that has had limited success in treatment by conventional measures. This project first set out to develop a diagnostic tool for neuropathic pain to evaluate whether Acetyl-L-Carnitine would be an effective treatment option.

Findings: Using principles of neurotransmission, hot and cold water applications were used to assess pain sensory dysfunction in patients and controls. The diagnostic test was successful in separating patients from controls, demonstrating its utility in assessment in pain-based disorders.

Implications: With an adequate assessment tool, Acetyl-L-Carnitine can be properly evaluated as a possible treatment for neuropathic pain, such as those found in Carpal Tunnel Syndrome.