Effect of Keytones in mouse model of Autism

Students: Jenna Dobry, Jessica Naidu

Type of project: Nutraceutical, Basic, Translational

Grant Type: Undergraduate

Year Awarded: 2015, 2016

Supervisor: Dr. Rho

Institutions Affiliated: University of Calgary

Description: Autism is a neurodevelopmental disorder characterized by poor social and communication skills, cognitive rigidity, and lack of emotional regulation. Keytones are a form of energy the body musters when sugars are of low supply and have unique metabolic properties. The proposed project seeks explore the impact of keytone bodies on behavioural improvements in a rat model of autism, so as to learn their therapeutic mechanism in addition to evaluate its effectiveness. As autism is robustly resistant to treatment, this could be a major advance in treatment of the disorder.