Endocannabinoid Signalling in Anxiety

Type of project: Basic, Translational, Nutraceutical, Mind and Body

Principal Investigator: Dr. Mathew Hill

Institutions Affiliated: University of Calgary

Students: Kowther Hassan (UGRAD), Haley Vecchiarelli (UGRAD), Kira Leitl (UGRAD)

Awards funded to project: 3

Background: Stress inhibits endocannabinoid signaling within the amygdala, which results in anxiety. Exactly how this process occurs is not well understood, though this project seeks to explore this phenomenon

Findings: This is a currently funded project pending results

Implications: Marijuana has been reported to have anti-anxiety properties by acting on the endocannabinoid system and this project explores the process by which this might occur. While marijuana could be used to achieve these effects, other studies have indicated that exercise would result in similar increases in endocannabinoids, offering a naturopathic option to manage anxiety.